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KMID : 0191120080230010156
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Journal of Korean Medical Science
2008 Volume.23 No. 1 p.156 ~ p.160
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Histiocyte-Rich Reactive Lymphoid Hyperplasia of the Liver: Unusual Morphologic Features
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Park Ho-Sung
Jang Kyu-Yun
Moon Woo-Sung
Kim Young-Kon
Cho Baik-Hwan
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Abstract
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Reactive lymphoid hyperplasia (RLH) of the liver is a rare entity and has also been termed nodular lymphoid lesion or pseudolymphoma of the liver. We report a case of hepatic RLH exhibiting unusual histiocyte-rich histologic features in a 47-yr-old woman in conjunction with a renal cell carcinoma. A follow-up computed tomography scan was done 14 months after a right radical nephrectomy for renal cell carcinoma revealed a nodular lesion in segment 5 of the liver. The lesion was interpreted as metastatic renal cell carcinoma or hepatocellular carcinoma based on the history of the patient and radiologic findings. Wedge resection of segment 5 was done with sufficient distance from the mass. Microscopically, the lesion was composed predominantly of peculiar histiocytic proliferation and was characterized by lymphoid aggregates forming a lymphoid follicle with germinal centers. The present case and prior cases reported in the literature suggest that RLH of the liver appear to be a heterogenous group of reactive inflammatory lesions that are often associated with autoimmune disease or malignant tumors.
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KEYWORD
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Pseudolymphoma, Liver Neoplasms, Lymphoid Hyperplasia, Reactive
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